Coumarins and derivatives
Apexbio Technology LLC HX 531 188844-34-0 10mg
HX 531 (CAS 188844-34-0) is a small-molecule antagonist targeting the retinoid X receptor (RXR) It modulates RXR-associated signaling pathways thereby influencing both tumorigenic and metabolic biological processes HX 531 exerts its biological activity by antagonizing RXR which results in cell cycle arrest at the G0/G1 phase and modulation of leptin-dependent pathways and the p53-p21Cip1 signaling axis In rodent models HX 531 demonstrates an inhibitory activity with an IC50 value of approximately 18 nM Based on these pharmacological properties HX 531 holds research potential in the study of metabolic disorders obesity diabetes and cancer biology
Apexbio Technology LLC HX 531 188844-34-0 5mg
HX 531 (CAS 188844-34-0) is a small-molecule antagonist targeting the retinoid X receptor (RXR) It modulates RXR-associated signaling pathways thereby influencing both tumorigenic and metabolic biological processes HX 531 exerts its biological activity by antagonizing RXR which results in cell cycle arrest at the G0/G1 phase and modulation of leptin-dependent pathways and the p53-p21Cip1 signaling axis In rodent models HX 531 demonstrates an inhibitory activity with an IC50 value of approximately 18 nM Based on these pharmacological properties HX 531 holds research potential in the study of metabolic disorders obesity diabetes and cancer biology
Apexbio Technology LLC 3-Carboxy-7-Hydroxycoumarin 779-27-1 100mg
3-Carboxy-7-Hydroxycoumarin (CAS 779-27-1) is a coumarin-based fluorescent molecule It is characterized by blue fluorescence emission upon excitation with ultraviolet light Structurally it features a carboxyl group that enables conjugation via carbodiimide activation (e g EDAC-mediated formation of succinimidyl ester intermediates) allowing covalent attachment to amine-containing residues in proteins and nucleic acids Based on these properties 3-Carboxy-7-Hydroxycoumarin is commonly employed in biochemical research for fluorescent labeling including analysis of protein protein interactions nucleic acid visualization and biomolecule detection assays
Apexbio Technology LLC 3-Carboxy-7-Hydroxycoumarin 779-27-1 1g
3-Carboxy-7-Hydroxycoumarin (CAS 779-27-1) is a coumarin-based fluorescent molecule It is characterized by blue fluorescence emission upon excitation with ultraviolet light Structurally it features a carboxyl group that enables conjugation via carbodiimide activation (e g EDAC-mediated formation of succinimidyl ester intermediates) allowing covalent attachment to amine-containing residues in proteins and nucleic acids Based on these properties 3-Carboxy-7-Hydroxycoumarin is commonly employed in biochemical research for fluorescent labeling including analysis of protein protein interactions nucleic acid visualization and biomolecule detection assays
Apexbio Technology LLC Coumarin 6 38215-36-0 10mg
Coumarin 6 (CAS 38215-36-0) is a fluorescent dye utilized primarily as a tracer in biomedical research for particulate drug delivery systems Coumarin 6 facilitates the visualization and analysis of particle distribution trafficking and cellular uptake processes in vitro and in vivo It is applied to study biological mechanisms related to transport and localization of therapeutic molecules and their interactions with cellular compartments Based on these properties Coumarin 6 holds research potential in evaluating drug delivery dynamics cellular internalization pathways pharmacokinetic behavior and disease-related investigations
Apexbio Technology LLC Coumarin-3-carboxylic Acid 531-81-7 200mg
Coumarin-3-carboxylic Acid is a coumarin-derived small molecule commonly applied as an investigative tool in biomedical research focusing on signal pathway regulation It is utilized to modulate enzymatic activities and cellular signaling pathways Coumarin-3-carboxylic Acid s biological activity has been studied in the context of its lanthanide complexes for inhibitory effects on cell growth in K-562 cell lines In cell-based studies it demonstrates antiproliferative activity in K-562 cells Based on these pharmacological properties Coumarin-3-carboxylic Acid holds research potential in elucidating biological mechanisms underlying hematologic malignancies and related diseases
Apexbio Technology LLC 3-Nitrocoumarin 28448-04-6 5mg
3-Nitrocoumarin (CAS 28448-04-6) is a selective inhibitor of phospholipase C- (PLC- ) an enzyme involved in cellular signal transduction through the hydrolysis of membrane phospholipids and subsequent generation of secondary messengers By suppressing PLC- catalytic activity 3-Nitrocoumarin disrupts related intracellular signaling pathways thereby enabling investigation of PLC- -mediated mechanisms in various physiological and pathological contexts This compound is widely utilized in studies focused on elucidating the roles of PLC- in disease models and fundamental biomedical research
Sigma Organic Chemistry 2- Ethylamino ethanol | 100ml | 110-73-6 | MFCD00002841
2- Ethylamino ethanol , 100ml
About this item:
CAS #: 110-73-6
MDL #: MFCD00002841
Purity: ≥98
Molecular Weight: 89.14
UNSPSC Code: 12352100
Sigma Organic Chemistry 6-Chloro-4-hydroxycouma | 5G | 19484-57-2 | MFCD00239399
6-Chloro-4-hydroxycouma , 5G
About this item:
CAS #: 19484-57-2
MDL #: MFCD00239399
Purity: ≥97
Molecular Weight: 196.59
UNSPSC Code: 12352100
Indofine Chemical MYRICETIN, Flavonoid & Coumarins, 529-44-2, 0.98, 50 mg
MYRICETIN, Flavonoid & Coumarins, 529-44-2, 0.98, 50 mg
Indofine Chemical Linarin With Hplc, 5 Mg
LINARIN with HPLC, Flavonoid & Coumarins, 480-36-4, 98.5% by HPLC, 5 mg
Indofine Chemical 5,6,7,3',4'-Pentame, 98%, 5 Mg
5,6,7,3',4'-PENTAMETHOXYFLAVONE, Flavonoid & Coumarins, 2306-27-6, 98%, 5 mg
Sigma Organic Chemistry 4-Bromomethyl-7-methoxycoumarin | 5G | 35231-44-8 | MFCD00006869
CAS #: 35231-44-8
MDL #: MFCD00006869
Purity: >97 %
UNSPSC Code: 12352100
Molecular Weight: 269.09
Sigma Organic Chemistry Coumarin 6 | 5G | 38215-36-0 | MFCD00041869 | 0.98
Coumarin 6, 5G
About This Item:
Storage: room temp
EINECS Number: 253-830-2
Sigma Organic Chemistry 3-Aminocoumarin | 1G | 1635-31-0 | MFCD00016965
3-Aminocoumarin , 1G
About this item:
CAS #: 1635-31-0
MDL #: MFCD00016965
Purity: ≥97
Molecular Weight: 161.16
UNSPSC Code: 12352100